Triple-negative breast cancer

Breast cancer is a type of cancer that forms in breast cells. It consists of accelerated and uncontrolled proliferation of glandular epithelial cells. They are cells that have greatly increased their reproductive capacity.

After skin cancer, breast cancer is the most common type of cancer diagnosed in women. Breast cancer can occur in both men and women, but it is much more common in women.

Breast carcinoma is the leading cause of cancer death in women in our country. Studies have allowed a new classification of breast cancer which highlights the triple negative subtype that take its name due to the absence of expression of estrogen receptors, progesterone and Her2-Neu. This subtype has aroused great interest in Oncologists specialists for the poor response to the available therapy, showing resistance to the various treatment modalities such as hormone therapy and white therapies, its manifestation in young patients, with rapidly growing tumors, with high frequency of lymph node involvement, distance and recurrence.

The percentage of these tumors with respect to the total number of cancers varies between 6 and 28% of all breast tumors. When classified by age, its prevalence is higher in patients diagnosed before the age of 50.

Due to the absence of specific treatment guidelines for this subgroup, triple negative breast cancers are managed with standard treatment; however, such treatment leaves them associated with a high rate of local and systemic relapse.

The following are three common characteristics of triple negative breast cancer:

  • It is considered to be more aggressive and has a worse prognosis than other types of breast cancer, mainly because there are fewer targeted medications that treat this cancer. Studies have shown that triple negative breast cancer is more likely to spread beyond the breast and is more likely to come back after treatment.
  • Tends to be of a greater degree than other types of breast cancer.
  • It is usually a type of cell called “basal-like,” which means that the cells resemble the basal cells that line the breast ducts.

Despite the diagnostic and therapeutic advances, its prognosis continues to depend mainly on the extent of the disease at the time of detection. Hence, prevention, taking measures to reduce the likelihood of getting cancer, as well as getting an early diagnosis remains the best option. Therefore, it is important to take into account the following recommendations:

  • Consult your doctor about breast cancer screening. Talk to your doctor about when to start breast cancer screenings and tests, such as clinical breast exams and mammograms.
  • Become familiar with your breasts through self-examination to become aware of breast cancer. Performing a sporadic review of your breasts. If you notice any changes, lumps or other unusual signs in your breasts, talk to your doctor immediately.
  • If you drink alcohol, do so in moderation.
  • Exercise most days of the week.
  • Limit postmenopausal hormone therapy. Combined hormone therapy may increase the risk of breast cancer.
  • Choose a healthy diet.

Being aware of breast cancer cannot prevent this disease, but it can help you better understand the normal changes that your breasts are going through, as well as identify unusual signs and symptoms.