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The biggest home of melanoma: Queensland, Australia

Melanoma is one the most common cancers in adolescence and young adulthood with incidence rates similar as soft tissue sarcomas and central nervous system tumors. Melanoma is an aggressive cancer with ongoing investigations in possible future treatments; so there is so much research to do before we can find a definitive solution. In recent years, …

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The truth about contrast agents used in CT and MRI

Anatomical and physiological imaging using CT and MRI is a key role in the diagnosis of patients nowadays, although they can be performed without any contrast agent, the use of these agents markedly increases the sensitivity and specificity of lesion detection. Giving an example, the physiological changes in tumor microenvironment and organ perfusion can be …

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Nivolumab + Ipilimumab efficacy on NSCLC patients with a high tumor mutational burden

The tumor mutational burden has emerged as a potential biomarker of benefit to asses which patients are suitable for a specific treatment. There was a study, Hellman et al 2018, in which they measured the efficacy of Nivolumab plus Ipilimumab in patients with non-small cell lung cancer (NSCLC) in a phase 3 trial. They examined …

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The importance of immunohistochemical marker in the detection and identification of lung cancer

Lung cancer is the leading cause of death from cancer worldwide and the subtype of adenocarcinoma is increasing in incidence in many countries, especially among women. Lung adenocarcinomas easily become metastatic and, as the diversity of chemotherapeutic agents increases, with differential efficacy against cancers from different sites, the importance of determining the primary source of …

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